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It has been announced that Pharmira Co., Ltd. commenced development of a technology for Continuous Manufacturing (CM) of active pharmaceutical ingredients (APIs) and intermediates and a contract development and manufacturing business using CM technology.
Aiming to transform the manufacturing technologies of APIs and intermediates, companies with specialized technologies and functions have come together to carry out contract development and manufacturing services. Following drastic changes in the environment surrounding APIs and intermediates in recent years, further acceleration of pharmaceutical development and building a stable supply network for APIs have become urgent issues, especially against the threat of infectious diseases.
By introducing CM technology as an innovative new technology in response to these environmental changes, it is expected that the time required for development of manufacturing methods in the pharmaceutical development stage will be shortened. CM technology is also expected to improve the efficiency of commercial production of pharmaceutical ingredients by conserving manpower and space and to enable advanced quality assurance for high-quality pharmaceutical products.
In order to meet diverse customer needs, the joint venture will use both well-established batch manufacturing technology and innovative CM technology to provide full-range, one-stop manufacturing services of APIs and intermediates, from development of drug manufacturing methods to manufacture of APIs for clinical trials and commercial production. Upon introduction, CM will be applied mainly to the reaction and crystallization processes, which are expected to have significant benefits by switching to CM. By applying CM from the development stage, it is possible to accelerate the development of pharmaceutical products while ensuring 
high quality and process safety.
Pharmira Co., Ltd is a JV with investments from Shionogi Pharma Co., Ltd., Chiyoda Corporation, Taisei Corporation, Fujimoto Chemicals Co., Ltd., Takenaka Corporation, Yokogawa Electric Corporation, and Nagase & Co., Ltd.