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Summary
As ARC Advisory Group has previously reported, Dassault Systèmes (DS) has moved from being a pure-play PLM supplier to an innovative platform supplier of design, simulation, manufacturing, and data 
management solutions. The company illustrated some of its newer technologies and solutions at its recent SIMULIA brand Analyst Day event at its campus in Rhode Island. DS focused on its 3DEXPERIENCE simulation platform and SIMULIA analysis applications that integrate design with multiphysics simulation.
The company’s simulation strategies align with its vision to “harmonize product, nature and life.” According to the company, its SIMULIA brand enables this vision by increasing simulation powers for sustainable innovation using multi-physics and multiscale technology and by growing its global community of partner innovators. Dassault Systèmes presented updates on additive manufacturing, designing new electronic vehicles, simulation “democratization,” the digital 3DEXPERIENCE Twin, and how these solutions are delivered on the company’s 3DEXPERIENCE platform.
Some examples of how the company’s customers use the SIMULIA applications for additive manufacturing, healthcare, and next-generation vehicle design and manufacturing follow.
SIMULIA and Additive Manufacturing
The SIMULIA simulation and analysis applications address important aspects of product design, including process, multiphysics, and materials for additive manufacturing (AM). The technology incorporates material properties to help determine material performance characteristics such as durability, density variations, and strength. It can combine these properties with thermal dynamics and other material considerations, including material evolution, during and following the 3D printing process. The technology can use data-driven physical and virtual representations of real entities to help solve challenges from manufacturing or additive printing.
Dassault Systèmes’ 3DEXPERIENCE platform uses digitization to help eliminate silos, improve speed-to-market, and unite functions from design to engineering to manufacturing and from supply chain to the business. AM enables new design practices that can capture functional specifications, generate and validate conceptual shapes, determine concept trade-offs, and generate shape modeling and validation. These help optimize AM design.
3DEXPERIENCE, SIMULIA, and Digital Healthcare
According to the company, the future for the 3DEXPERIENCE platform for simulated healthcare will include studying molecular drug effects on the human body, assisting virtual clinical trials, and performing testing that simulates the interactions of real human behavior for actionable in-sights. Examples include simulating human hearing, the human heart, or human limbs for orthotics and prosthetics. Movement and the stress from running, walking, and other movements requires simulating human behavior to test the device properly. Additionally, determining how specific drugs can interact and affect individual human organs like the heart can depend upon the heart type or specific heart disease.
Virtual Human Modeling
The use of Virtual Human Modeling (VHM) enables companies to create designs that consider the biomechanics of implants, electromagnetic safety of medical devices and equipment, and real-world environment in which people live. VHM can help determine stresses on the device or how drug delivery works by simulating the performance on individualized body types.
To understand human variations, the human body needs to be viewed as a holistic dynamic and adaptive system. Virtual or simulated patients can be used to augment clinical testing to help improve compliance and reduce defects.
Dassault Systèmes’ 3DEXPERIENCE platform enables the development and virtual testing of personalized medical devices and implants, such as prosthetic limbs. It can also be used to help diagnose and treat heart diseases and for other personalized therapeutics. Since the 3DEXPERIENCE platform is available in the cloud, even the smallest medical device companies can now benefit from the speed and flexibility of high-performance computing. Any life sciences company can immediately scale up virtual testing securely and collaboratively while managing infrastructure and clinical testing costs.
The Living Heart Model
Dassault Systèmes has extensive experience on different organ types and medical device simulations to help companies reduce recalls and risk. For example, the Living Heart Model can be used for the design and virtual testing of annuloplasty rings used to reduce the severity of mitral regurgitation. In addition, a damaged human heart can be modeled to simulate and show potential problems with medical devices and enable the physician to determine potential remedies using models that closely match the patient’s real heart. This technology can be used to better understand how a target patient population may respond to a novel medical device and thus help reduce potential implant recalls.
How Therapeutics Affect the Heart
It is important to understand how the individual’s heart interacts with the rest of the body as well as how a drug or device will affect the heart. For example, a drug’s interaction with one individual’s heart may affect the rhythm of the heart differently than for someone else. Dassault Systèmes’ SIMULIA and BIOVIA applications on the 3DEXPERIENCE platform enable multiscale modeling of the human heart (including 
molecular interactions, biochemical pathways, cellular biophysics, tissue mechanics, and whole heart and body physiology) to better predict the likelihood of drug-induced arrhythmia.
Pharmaceutical companies can use this technology to predict drug safety based on the anatomy, physiology, and dosage. The model can help answer questions such as: “How does a drug affect the ion channel? How does the drug affect cell behavior?’ and “What types of cardiac cells are affected?” Multiscale modeling provides the ability to understand the anatomy of the patient’s heart, the quality of the data image, and knowledge for full-scale heart simulations.
The 3DEXPERIENCE platform ultimately provides the ability to compare the same drug at different dosage levels and see how these affect the heart in an efficient manner. Moreover, virtual testing can be even more accurate than animal testing.
Computational Modeling and Simulation for FDA Compliance
Future personalized medicine will make more use of simulation for real-world testing. The FDA is working with SIMULIA and other vendors to guide adoption of new simulation technology and methods of medical devices to reduce the time and cost required for bench testing, animal testing, and other clinical trials.
Electric and Autonomous Vehicles
Dassault Systèmes aims to “democratize” simulation by providing simulation process integration and 
design optimization for the automotive industry as well as other industries. For automotive developers, the company’s simulation targets include achieving zero defects, reducing cost, and reducing time-to-market by shortening design cycles.
In one example, SIMULIA demonstrated how its applications can be used to capture design simulation methods to reduce design time and costs for vehicle hood design. The company’s solutions here incorporate multiphysics to align processes with functional requirements and business goals.
The company continues to deliver solutions that address electric, connected, and autonomous vehicles; and the new customer vehicle experience; while helping improve quality and reduce costs.
3DEXPERIENCE Twin for Maintenance
The 3DEXPERIENCE Twin couples a virtual model and physical model. Dassault Systèmes is enabling the use of a twin simulation model for virtual design and to understand operating conditions for preventive maintenance. Data management and processing using the 3DEXPERIENCE platform expands the breadth of the digital thread for data manipulations. The platform delivers a framework that includes requirements, functional services or models, logical component models, and physical component models that compile all the information required to support the vehicles’ parts simulation.
From Maintenance 1.0 to Maintenance 2.0
Dassault Systèmes is also improving the maintenance experience for auto manufacturers and their customers by moving from reactive maintenance, which is costly and less effective; to predictive analytics-driven maintenance. This “Maintenance 2.0” approach considers environmental conditions, usage, and even human behavior (such as braking behavior) instead of largely mileage-based scheduled maintenance.
Conclusion
Dassault Systèmes’ 3DEXPERIENCE platform and the company’s SIMULIA brand simulation applications can provide value across multiple industrial, healthcare, and transportation sectors. The company’s multiscale, multiphysics simulation models have been proven to enable better designs, better testing and validation approaches, better manufacturing, and better product support.
In medicine, failure is expensive from the cost and brand points of view and can lead to other potential risks, including potential deaths or malperformance. Dassault Systèmes simulation efforts focus on features that will offer value to medical device manufacturers, pharmaceutical companies, and – ultimately - the clinician. In addition to working with heart surgeons and medical specialists to deliver personalized cardiovascular treatments, the company is also working with orthopedic surgeons to build foot models for procedures and new orthotics using simulation. By adopting virtual human modeling to understand human interactions, behaviors, and stresses, medical device manufacturers and medical practitioners can transform the healthcare and medical device industry.
It’s has been interesting for ARC Advisory Group to follow the many new and transformative applications that Dassault Systèmes, its brands, and its partners have been pursuing for its innovative technologies, driven by the company’s vision to “harmonize products, nature and life.”
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Keywords: Dassault Systèmes, SIMULIA, Additive Manufacturing, Product Design, Personalized Healthcare, Multiphysics, Multiscale Simulation, ARC Advisory Group.